Joint Pain and Inflammation

Joint Pain and Inflammation

Joint Pain and Inflammation¬†ūü홬†

One of the most popular uses for cannabinoids like CBD and THC is using them as an alternative for managing pain and inflammation (1).

After studying this plant for years, I always found it so interesting that this one plant could be used for so many different things and the safety profile was something that caught my eye immediately. Previously working in the emergency care setting, I know first-hand of the opioid crisis here in America. I know how important it is to find something that we can use to get pain and inflammation relief, all while cutting down on drug addiction and practically eliminating overdose related deaths. So, when I come across great studies about a plant that has a great safety profile and offers the relief that those that get hooked on pain pills are looking for, you better believe I am going to share it! Check this out. 

According to the European Journal of Rheumatology (EJR), a peer-reviewed medical journal, the use of exogenous cannabinoids (CBD, THC, etc.) shows a promising future for offering acute/chronic pain and inflammation relief (1). The study shows that these plant compounds interact with our endogenous receptor system to have immunomodulatory effects that can influence pain perception and control the inflammatory response (1).  

The truth is that the endocannabinoid signaling molecules, G-coupled cannabinoid receptors, and their enzymes are involved in ligand biosynthesis and inactivation (1). The study stated that we can use cannabinoids (CBD, THC, etc.) to offer anti-nociceptive effects, which means blocking the detection of pain (1).  

In addition to blocking the perception of harmful stimuli through the sensory neurons (pain perception), the ECS also plays a role in regulating immune response, which means controlling the inflammatory response, ultimately stopping it from over reacting (1). This is important to note because pain and inflammation go hand in hand because swelling activates these sensory neurons, which is a way in which we detect pain.  

According to EJR, endocannabinoids regulate immune response, which includes the innate (monocytes, macrophages, neutrophils, natural killer (NK) cells, eosinophils, basophils, mast cells) and adaptive immune response (1). This is huge because when there is pain and inflammation (whether acute or chronic) we have an immune response that discharges these cells to the area. Modulating the behavior of the ECS to reduce swelling (controlling white blood cells) and inactivate sensory neurons (analgesic effects) will help to aid in the pain and inflammation relief that was associated with cannabinoid use (1).  

In summary, cannabinoids were shown to offer pain and inflammation relief through activation of this amazing receptor system we all have, the endocannabinoid system. The best part? These natural plant compounds could practically eliminate overdose related deaths! Talk about a life saver! 

Using cannabinoids like CBD and THC can have varying effects from one person to the next. If you are new to cannabinoids, it is always best to reach out for advice to determine what products may suit you best. If you are new to CBD or THC, it is always best to consume in a controlled manner. Start low and slow until you find the dose that works best for you, making sure not to overdo it to uncomfortable levels. Our products have different CBD to THC ratios and different strengths, so it is important to find what product suits you best. If you have any questions, reach out to us so we can get to know you a little and find what products may work best for you. 


Brandon Farless ūüźĚ


*This information is for educational purposes only and simply sharing information pertaining to this study. No medical advice or claims are being made. 


1.¬†¬†¬†¬†Barrie, N., & Manolios, N. (2017). The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease.¬†European journal of rheumatology,¬†4(3), 210‚Äď218.

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